TRAIL receptor-2

abbr. TRAIL-R2. This human receptor for the cytotoxic ligand TRAIL belongs to the TNF receptor superfamily. TRAIL receptor-2 contains a cytoplasmic death domain necessary for the induction of apoptosis, which is the result of overexpression of the receptor. The receptor has been designated death receptor-5 (DR5). This receptor has been identified independently as KILLER and is known also as TRICK2. DR5 is located on chromosome 8p21. Owing to its homology to other members of the TNF receptor superfamily the receptor is being referred to also as TNFRSF10B [ ... ... ... ...
 
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Entry last modified: August 2001