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TRAIL

[TNF-related apoptosis inducing ligand] The sequence of TRAIL (281 amino acids) was identified in a human heart atrium cDNA library and a murine cDNA library prepared from the 7B9 T-helper cell line. Both cDNAs encode a type 2 membrane protein (N-terminus inside). The gene maps to human chromosome 3q36. TRAIL is called also APO-2 ligand (abbr. APO-2L). The gene encoding this ligand has been described also as TL2 (TNF-like-2) (Tan et al, 1997). Based upon homology with other members of the TNF ligand protein superfamily the protein is referred to also as ... ... ... ... ... Subscribe to continue reading! ... ...

 

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