TSSC6

[tumor-suppressing subchromosomal transferable fragment cDNA 6] This gene has been isolated by Koi et al (1993) as a subchromosomal transferable fragment of human chromosome 11p15, the introduction of which into the rhabdomyosarcoma cell line RD suppresses in vitro growth of the cells. The TSSC6 cDNA encodes a predicted protein of 290 amino acids. The gene lies in a region that contains many imprinted genes but TSSC6 appears to escape genomic imprinting and is not imprinted significantly in any of the fetal or extra-embryonic tissues examined (Lee et al, 1999)

TSSC6 appears to be the human counterpart of murine PHEMX [pan-hematopoietic expression gene X]. The ... ... ... ...
 
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Entry last modified: March 2004