Tetrastatins

Tetrastatins are bioactive fragments (see also: cryptides) derived from the COL4A4 gene (collagen-4-alpha-4 chain). They have been shown to inhibit the proliferation and migration of human umbilical vein endothelial cells in vitro and are therefore thought to possess anti-angiogenic properties in vivo (Karagiannis and Popel, 2008). Note: the complete NC1 domain of collagen-4-alpha-4 is being referred to as Tetrastatin.

Tetrastatin-1 (LPVFSTLPFAYCNIHQVCHY; Leu-Pro-Val-Phe-Ser-Thr-Leu-Pro-Phe-Ala-Tyr-Cys-Asn-Ile-His-Gln-Val-Cys-His-Tyr) corresponds to residues 1514-1533 of the COL4A4 gene: ... ... ... ...
 
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Entry last modified: April 2013