TOLL |
Toll-1 |
Rs-AFP4 |
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This Drosophila melanogaster protein, encoded by gene CG5490 and being referred to also as Toll-1, is the founding member of the TLR family and was identified originally as a component of the signaling pathway that induces dorsal-ventral polarity in the fly embryo (Anderson et al, 1985). The Toll pathway plays a key role in dorso-ventral axis establishment as well as in several other developmental processes (Belvin and Anderson, 1996).
The Toll signaling pathway is required also for innate immune responses against fungi and Gram-positive bacteria in Drosophila
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