VF |
VFDSLGGYEVHGF |
Ranacyclin E |
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VFD-7 is a natural intracellular peptide, VFDVELL, identified originally in HEK293 cells (Berti et al, 2009). The peptide is found also in MCF7 breast cancer cells and SH-SY5Y neuroblastoma cells (Gelman et al (2011).
Fricker et al (2012) have identified the peptide as a proteasome product in HEK293 cells and shown that it is derived from human FKBP1A [FK506-binding protein 1A]. Thus it can be considered as a cryptide.
Russo et al (2012) have reported that the VFD-7 peptide modulates the interactions of calmodulin and 14-3-3-epsilon
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