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VLA-2

[VLA-2(+), VLA-2(-), VLA-2(low), VLA-2(high), VLA-2(int)]

[very late activation antigen 2] Very late activation antigens are a family of heterodimeric transmembrane proteins that belong to the integrin family of cell adhesion molecules (Hynes, 1987; Ruoslahti, 1991). These antigens consist of a distinct alpha subunit non-covalently linked to a common beta subunit. Their name refers to the observation that beta-chains increase in amount and additional alpha-subunits appear after long-term T-cell activation (Hemler et al, 1987).

VLA-2 protein is a collagen receptor (Nieuwenhuis et al, 1985) consisting of a unique alpha chain (platelet protein GPIa) and a beta subunit common to other adhesion receptors, forming the glycoprotein complex GPIa/IIa on ... ... ... ... ... Subscribe to continue reading! ... ...

 

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