amidated Gastrin |
amidorphin |
CD279 |
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This term refers to a posttranslational modification found in nearly half of all known peptides, where the C-terminal carboxyl group is replaced by an amide group (-NH2). Amidated peptides, which include many neuropeptides, peptide hormones and antimicrobial peptides, usually have an extended half-life in the bloodstream because amidation makes them less sensitive to proteolytic degradation by proteases present in the extracellular environment. This permits these peptides also to function as long-range signalling molecuoles.
While the C-terminal carboxyl group can be protonated or deprotonated, depending on pH, amidated peptides
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