Caspase-8 related protein |
Caspase-9 |
RG14620 |
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Caspase-8s is a short isoform of caspase-8 that encodes the first and part of the second death effector domain, missing the C-terminal caspase domain. Caspase-8s has been shown to bind to FADD, the adaptor protein in the death-inducing signaling complex. Overexpression of caspase-8s increases the sensitivity to the apoptotic stimulus by FAS agonistic antibody CH11. Caspase-8s may act as a promoter of cell death by apoptosis through binding to FADD and is involved in the regulation of apoptosis.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary
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