GADD |
gadd34 |
IVKNLQNLDPSHRISDRDYMGWMDF |
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[growth arrest and DNA damage induced gene-7] This hamster gene belongs to the family of GADD genes the expression of which is induced by various genotoxic and non-genotoxic stresses (Hollander et al, 1996). gadd7 cDNA does not contain an appreciable open reading frame and does not appear to encode a protein product, but instead may function at the RNA level.
Expression of gadd7 has been found to be induced by alkylating agents, such as methyl methanesulfonate (MMS), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and mechlorethamine HCl (HN2), oxidizing agents, such as hydrogen peroxide, and growth arrest signals, such as medium starvation. Overexpression of gadd7 leads to a decrease in cell growth (Crawford et al, 1996.
Crawford et al (1996) have identified an RNA of 950 bases in hamster HA1 fibroblasts,
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