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metadherin

[also: metastasis adhesion protein] abbr. and approved gene symbol: MTDH. This protein has been identified by Brown and Ruoslahti (2004). The murine cell surface protein has been shown to mediate lung metastasis of breast cancer cells.

Metadherin has a transmembrane domain in its N-terminal half and a lung-homing domain in its long C-terminal half. Injection of human embryonic kidney cells expressing mouse metadherin into nude mice causes accumulation of these cells in the lung. This effect is reduced by antibodies reactive to the lung-homing domain of metadherin (Brown and Ruoslahti, 2004). Treatment of metadherin-positive ... ... ... ... ... Subscribe to continue reading! ... ...

 

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