Parthanatos |
partner of burs |
Nur-77-derived BCL2-converting peptide with 20 amino acids |
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A form of cell death by apoptosis, observed in myeloma cells, that is morphologically and mechanistically distinct from classical apoptosis (Zhang et al, 2005). The process is characterized by chromatin condensation without nuclear fragmentation, and 'partitioning' of cell constituents into two components: a single, large bleb containing soluble protein and free ribosomes, and a region containing the nucleus, organelles, and rough endoplasmic reticulum. These morphologic features are observed also when the actin and tubulin cytoskeletal systems are inhibited. This type of apoptosis depends on the expression of caspases and can be inhibited by IL6 and overexpression of BCL2. Partitioning apoptosis has been observed also in a variety of tumor
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