SFRNGVGTGMKKTSFQRAKS |
sFRP1 |
LAMC1 |
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[sFRPs]
[secreted frizzled-related proteins] These secreted proteins constitute a protein family related to frizzled. They show a distinct expression pattern and do not result from differential splicing of the known frizzled genes but are encoded by distinct genes (Rattner et al, 2002). sFRP proteins modulate interactions between Wnt family receptor proteins, Wnt family ligands, and Frizzled membrane receptors and influence biological processes ranging from developmental cell fate, cell polarity and adhesion, to tumorigenesis and cell death by apoptosis. These proteins do not only bind to Wnt family
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