SLIPHAINAVSAIAKHFamide |
SLIT1 |
alpha-1-T-glycoprotein |
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gene CG8355; abbr. sli. This gene from Drosophila melanogaster plays a role in the development of the nervous system. It is a secreted chemorepellent molecule providing guidance cues for outgrowing axons (Kidd et al, 1999). The protein acts as a signaling ligand for the roundabout (Robo) receptor (Rothberg et al, 1990).
The human homolog is Slit-2. Related human genes are Slit-1 and Slit-3. Slit genes form an evolutionary conserved gene family in vertebrates and invertebrates (Brose et al, 1999).
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