spitz
gene symbol: spi. The Drosophila melanogaster gene Spitz (CG10334) encodes a 26 kDa transmembrane structurally similar to TGF-alpha that is expressed throughout the embryo. Spitz is considered the Drosophila melanogaster homolog of TGF-alpha. For a homolog see also: Keren.
Spitz is involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development (Rutledge et al, 1992).
Spitz binds to the Drosophila melanogaster EGF receptor, DER
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