Suppressive E receptor |
suppressor/inducer T-cells |
BPP-3 |
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[suppressor endothelial cell]
This cell type has been described by Mulligan et al (2008). Suppressor endothelial cells are endothelial cells in the vasculature of tumors that are potential immune effector cells. Their activities are skewed by factors secreted from tumor cells towards immune suppression. Disruption of functions is seen with NK-cells (reduced expression of TNF-alpha, IFN-gamma), T-cells (reduced IFN-gamma production by CD8(+) T-cells; reduced IL2 production by CD4(+) T-cells), and macrophages (reduced phagocytosis and prostaglandin production, increased
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