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ALG2

[Apoptosis-linked gene-2]. A 22 kDa calcium-binding protein that promotes cell death induced by APO-1, T-cell receptor engagement, and synthetic glucocorticoids. The factor has been given the designation PDCD6 [programmed cell death-6].

ALG2 is involved also in neuronal survival and has been implicated in Alzheimer's disease (Vito et al, 1996). ALG2 has been shown to interact with kinase ASK1 (Hwang et al, 2002) and AIP1. Tarabykina et al (2000) have described isoforms of ALG2, one of which does not interact with AIP1.

Jang et al (2002) have created knock-out mice lacking expression of ALG2. These mice ... ... ... ... ... Subscribe to continue reading! ... ...

 

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