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Amelotin

approved gene symbol: AMTN. The human gene and the mouse gene (Iwasaki et al, 2005) encode secreted factors without significant homology to other sequences. Moffat et al (2006), who have cloned rat Amelotin, have reported that Amelotin is highly conserved in mammals but is absent in fish, birds, and amphibians.

Amelotin is a secreted factor produced by ameloblasts. Its expression appears to be restricted to maturation-stage ameloblasts in developing molars and incisors. The protein may play a role in the formation of dental enamel. Abbarin et al (2015) have reported that Amelotin promotes hydroxyapatite mineralization. Its binding affinity for hydroxyapatite is comparable to that of amelogenin ... ... ... ... ... Subscribe to continue reading! ... ...

 

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