|COPE Homepage||Bottom of page||Previous entry:
Janus kinase binding protein-1
please show your appreciation
by donating what you can afford.
[HLA-B-associated transcript 3; B-associated transcript 3] This gene, located within human major histocompatibility complex, has been identified by Banerji et al (1990). The protein (110 kDa) contains an amino-terminal ubiquitin-like domain. Sequence comparisons show that BAT3 is identical with scythe. Another designation for scythe is BAG-6 [BCL2-associated athanogene-6].
The rat ortholog, termed RLC34 by Wang and Liew (1994), is expressed predominantly in the germ cells of rodent testes. Ozaki et al (1993), have cloned the rat BAT3 cDNA and have shown that the encoded protein interacts with the tumor suppressor protein DAN. Kumar et al (2004) have reported that BAT3 interacts with IER3 [immediate-early response-3].
Wu et al (2004) have identified human BAT3 as a ricin A chain interacting protein. Ricin induces cell death by apoptosis by activating caspase-3 and this leads to the cleavage of BAT3. BAT3 is a caspase-3 substrate, as shown by the ability of zDEVD-fmk, a caspase-3 specific inhibitor, to prevent BAT3 cleavage and the absence of BAT3 cleavage in cells not expressing caspase-3. Silencing the expression of endogenous BAT3 suppresses ricin-induced apoptosis.
Copyright © 2012 by H IBELGAUFTS. All rights reserved.
ENTRY LAST MODIFIED: July 2006
See REFERENCES for entry BAT3.
Click BACKLINKS to see which COPE entries contain the term BAT3 .
|COPE Homepage||Top of Page|
|SUPPORT COPE | Santa Claus | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials|
|COPE is looking for long-term support from a company appreciating and committed to communication biology|
| Access to COPE is free only for academic institutions and non-profit organizations. |
OTHER USERS: must contact COPE and pay a site licence fee.