DNA

Extracellular DNA (abbr. eDNA) - also: cfDNA [Cell-free deoxyribonucleic acid] - and fragments derived thereof have been reported to act as a DAMPs [damage-associated molecular patterns] (for comparison see also: mitochondrial DNA, Extracellular RNAs) (for overview see also: Magna and Pisetsky, 2016).

eDNA has been shown to trigger the synthesis of complement factor B in macrophages in response to endogenous damage in a process that dependes on another danger signal, HMGB1 [high mobility group box-1], MyD88 and NF-kappa-B ... ... ... ...
 
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Entry last modified: December 2019