Bipotential stem cells |
BIR-2 |
Early pregnancy factor |
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Fraser et al (1999) have characterised two proteins in Caenorhabditis elegans, BIR-1 and BIR-2, that contain two copies of a BIR domain (see: IAP). BIR-1 is structurally related to mammalian survivin.
Overexpression of BIR-1 does not inhibit developmentally occurring cell death by apoptosis and inhibition of its expression does not increase apoptosis. Cytokinesis is impaired in knock-out embryos lacking BIR-1 with cells becoming multinucleate. This phenotype is suppressed partially by simultaneous expression of survivin
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