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CD24

Other designations:

30F1
B2A2
BA-1
HB8
HIS50 (monoclonal antibody recognizing the rat protein)
HSA [heat stable antigen] (rat, mouse)
J11d (JIId)
LR-1
Ly52
M1/69
Nectadrin (rat)
R13-Ag [R13 antigen]
SCLC surface antigen Cluster-4 (CL-4)

VIB E3
X62 heat stable antigen

The term CD24a has been used for the murine gene on chromosome 10 encoding HSA (Wenger et al, 1993). Wenger et al (1993) also cloned two other genes, which they designated CD24b (chromosome 8), and CD24c (chromosome 14) which appear unrelated and do not encode HSA.


CD24 is a glycosyl phosphatidylinositol-anchored protein (Pierres et al, 1987; Kay et al, 1990; Alterman et al, 1990) expressed on immature cells of most, if not all, major hematopoietic lineages, as well as in developing neurons (Nedelec et al, 1992; Shirasawa et al, 1993; Rougon et al, 1991) and embryonic intestinal, nasal, salivary gland, renal rat epithelial cells (Shirasawa et al, 1993), regenerating muscle (Figarella-Branger et al, 1993). CD24 is usually absent from cells that have reached their final differentiation stage. Expression of CD24 is strongly induced and then repressed again during maturation of T-cells and B-cells Allman et al, 1992; Bruce et al, 1981); Crispe and Bevan, 1987; Hardy et al, 1991; Husmann et al, 1988; Linton et al, 1989; Symington and Hakamori, 1984; Takei et al, 1981). Erythrocytes are an exception in that they maintain high levels of CD24 expression. CD24 is expressed also in keratinocytes (Magnaldo and Barrandon, 1996), epidermal Langerhans cells (Enk and Katz, 1994), and dendritic cells (Inaba et al, 1992; Ardavin and Shortman, 1992). CD24 is expressed as a major surface antigen on small cell lung carcinomas (Jackson et al (1992). It is expressed in a variety of carcinomas (Karran et al, 1995; Akashi et al, 1994; Weber et al, 1995).

Nielsen et al (1997) have generated knock-out mice lacking expression of CD24. These mice are characterized by a normal development of T-cells and myeloid cells but show a leaky block in B-cell development with a reduction in late pre-B-cells and immature B-cell populations in the bone marrow. Peripheral B-cell numbers are normal and no impairment of immune function is detected in these mice in a variety of immunization and infection models. Erythrocytes from these mice show a higher tendency to aggregate, are more susceptible to hypotonic lysis in vitro, and have a shorter life-span in vivo.

Lu et al (2000) have reported that a slight overexpression of CD24 in transgenic mice leads to depletion of B-lymphoid cells in the bone marrow, which may be caused by increased cell death by apoptosis of pre-B-cells.

For additional information on CD antigens see also: CD antigens MiniCOPE Dictionary.


See remarks in the CD antigens Dictionary section of this encyclopedia.
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