CGIF

[Cell growth-inhibitory factor] This factor of 23-25 kDa is produced by rat peritoneal exudate cells after induction with Enterococcus faecalis. The factor completely inhibits mitogenesis in thymocytes induced by Con A. CGIF also completely suppresses incorporation of tritiated thymidine by splenocytes stimulated by either Con A or bacterial lipopolysaccharides. CGIF also reduces the viability of these cells when added with mitogens such as Con A or bacterial lipopolysaccharides.

The factor appears to be distinct from interleukin-1 receptor antagonist (see: IL1ra) or TGF-beta. Yui et al (2003) have reported that CGIF, isolated from ... ... ... ...
 
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Entry last modified: May 2013