Caspase-8
abbr. CASP8. This enzyme is a member of a family of evolutionarily conserved cysteine protease proteins known as caspases. Many of these enzymes are part of a proteolytic cascade that plays a central role in cell death by apoptosis. Other designations are MACH, FLICE, and MCH5.
Eight different isoforms have been described for Caspase-8 (designated Caspase-8a, Caspase-8b, Caspase-8c, Caspase-8d, Caspase-8e, Caspase-8f, Caspase-8g, Caspase-8h) (Scaffidi et al, 1997). One splice isoform, designated
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