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danger signals

general term for any kind of mediator signalling damage to cells or tissues.

The Danger Theory, proposed by Matzinger (1994), can be seen as a mechanism paralleling the recognition of microbes involving pattern recognition receptors and microbe-associated molecular patterns and essentially states that the immune system, rather than recognizing pathogens per se, recognizes the damage caused either by sterile injuries or by pathogens (Matzinger, 1998, 2002). Collectively, these molecules that trigger immune reactions are being referred to as DAMPs [damage-associated molecular patterns; danger-associated molecular patterns].


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Entry last modified: November 2022



 
 
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