Dapaf-1

[Drosophila melanogaster Apaf-1/CED4 homolog] This protein, encoded by gene: CG6829, is the Drosophila melanogaster homolog of human APAF-1 and CED4, the corresponding gene from Caenorhabditis elegans. It has been isolated independently as HAC-1 and DARK. Two distinct forms of the protein have been isolated. Dapaf-1L (APAF-1 type) and Dapaf-1S (CED4 type). These two isoforms have been shown to activate distinct caspases. Loss of Dapaf-1 function has been shown to reduce apoptosis in embryo and in larval brain.

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Entry last modified: March 2003