GPR24 |
GPR28 |
Hi95 |
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[G-protein-coupled receptor-25] Zhang et al (2018) have identified the peptide hormone APELA as an endogenous ligand of the orphan receptor GPR25 [G-protein-coupled receptor-25] in non-mammalian vertebrates (zebrafish, spotted gars, and pigeons). GPR25 can also be activated by Apelin. The human receptor is not activated by either peptide.
GPR25 is expressed in a variety of tissues, including the testes and intestine of zebrafish / spotted gars / humans, implying potential roles of GPR25 signaling in many physiological processes in vertebrates.
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