HC21

[Cytokine 21, human] This gene was isolated as a cDNA from human lymphocytes stimulated with CD2 (Chang and Reinherz, 1989). It is expressed in T-lymphocytes and some T-cell lines that depend on IL2 for growth (see also: Factor-dependent cell lines).

HC21 encodes a secreted protein of 69 amino acids derived from a precursor of 92 amino acids. HC21 belongs to the family of chemotactic cytokines known as Chemokines (subgroup of CC-Chemokines. It is related closely to MIP-1-beta (macrophage inflammatory protein-1-beta; see: MIP).

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