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[IFN-gamma inducing factor] The new term IL18 (Interleukin-18; see also: Interleukins) is now used for this factor.

The gene encoding tis factor of 157 amino acids has been cloned by Okamura et al (1995). IGIF does not display sequence similarities to other known proteins. However, a survey of the sequence by fold recognition methods suggests that IGIF belongs to the IL1 family of cytokines. Murine and human IGIF show 65 % homology. Rat and murine IGIF display 91 % homology at both the nucleotide and the amino acid level. The biologically inactive precursor of 192 amino acids is processed into the biologically active form by one of the Caspases (Caspase-1 = IL1-beta Convertase).

IGIF is synthesized by Kupffer cells and macrophages after cell activation.

IGIF is an activity that induces IFN-gamma in T-cells in mice treated with Propionibacterium acnes and subsequently challenged with bacterial lipopolysaccharides. IGIF augments T-cell proliferation and NK-activity in cultures of human peripheral blood mononuclear cells.

Copyright 2012 by H IBELGAUFTS. All rights reserved.


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