INSL5

[insulin-like-5] This protein, identified by sequence homology (Conklin et al, 1999), belongs to the insulin gene superfamily and shows a complex two-chain peptide hormone constrained by three disulfide bonds in a pattern identical to insulin. The murine protein is being referred to also as Rif2 [Relaxin/insulin-like factor 2] (Hsu, 1999). Like insulin, INSL5 undergoes proteolytic processing from a propeptide in which a peptide resembling C-peptide located between the two hormone chains is removed to yield the A-chain (Insulin-like peptide 5 A chain; QDLQTLCCTDGCSMTDLSALC; ... ... ... ...
 
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Entry last modified: October 2013