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[inhibitor of TRAIL induced death] A collective term for proteins preventing cell death by apoptosis induced by TRAIL identified in a genetic screen utilizing the human TRAIL-sensitive colon carcinoma cell line SW480.
The authors have identified FLIP-S, BAX inhibitor-1, and BCLxL as candidate suppressors of TRAIL signaling and demonstrate that overexpression of FLIP-S and BCLxL are sufficient to convey resistance to TRAIL treatment in previously sensitive cell lines. Expression of FLIP-S and BCLxL also protects cells against
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