Immunoglobulin superfamily receptor translocation associated 5 |
immunologic accessory cells |
Dendritic cell-derived Ig-like receptor 1 |
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This hybrid protein is a chimeric tumor-targeted killer protein designed by Zhao et al (2004). ImmunoGrB comprises a single-chain antibody directed against erbB2 (neu) with an aminoterminal signal sequence, a Pseudomonas exotoxin A translocation domain, and a Granzyme B moiety. The strategy of using this immunotoxin is have this protein secreted by transfected cells, which then binds to tumor cells overexpressing the neu oncogen. Uptake of the construct and subsequent activation of Granzyme B causes tumor cell death. The authors have provided a proof of concept by demonstrating growth inhibition of xenotransplanted tumor cells in nude
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