erbB2

this is the same as p185erbB2, a receptor for EGF. The receptor is being referred to also as EGF receptor 2 [epidermal growth factor receptor 2]. This gene is related to erbB (see: erb) and is identical with the neu oncogene. Another designation is HER2. For a secreted splice variant see also: Herstatin. The previously used gene symbol, NGL [neuro/glioblastoma-derived], has been withdrawn.

Apart from its signalling role, erbB2 also has a role in the nucleus and functions as a transcription factor involved in the transcription of rRNA genes by RNA Polymerase I (Li LY et al, 2011).

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