inhibin-like peptide-1-31 |
inhibitor-1 of protein phophatase-2A |
Leu2 |
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Inhibin was purified from bovine and porcine follicular fluid and identified first as a gonadal hormone that potently inhibits pituitary synthesis and secretion of FSH (follicle-stimulating hormone) (FSH release inhibitor). The hormone also influences the development of granulosa cells and inhibits the FSH-stimulated synthesis of estrogens. The FSH-stimulated release of Inhibin can be potentiated by IGF-1 and is blocked by EGF and TGF-alpha.
Inhibins are related to TGF-beta
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