KSHV MTA |
KSHV orf7 |
NMUR1 |
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This open reading frame is contained within the genome of KSHV [Kaposi sarcoma-associated herpesvirus] KSHV) (HHV-8) [HHV-8 orf4] (Virgin et al, 1997). The gene, which gives rise to at least three different transcripts, encodes a complement regulatory protein, designated KCP [complement control protein] and shows homology to cellular proteins referred to as regulators of complement activation (Spiller et al, 2003). The protein is being referred to also as kaposica.
The protein inhibits the complement component of the innate immune response
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