LRQFLQKSLAAAAamide |
LRR5 |
differentiation antigens |
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[LRR]
[leucine-rich repeats] The LRR domain is structural motif of approximately 20-30 amino acids. These sequence motifs are present in many proteins from prokaryotes to eukaryotes. LRRs are a protein-protein interaction motif and as such are utilized in various molecular recognition processes, including signal transduction, cell adhesion, cell development, DNA repair and RNA processing (Kobe and Deisenhofer, 1994, 1995; Kobe and Kajava, 2001).
Many Toll-like receptors have been shown to contain multiple tandem copies of an LRR and it is thought that this motif participates in the recognition of pathogens by this class of receptors (Bell et al, 2003). Many proteins of the CLR family (NLR family
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