MCMV RR1 |
Mcol-B |
SLEB1 |
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[Murine collagenase-like A] The cDNA encoding this murine metalloproteinase (464 amino acids) has been cloned by Balbín M et al (2001). The encyme is 82 % identical with Mcol-B. Mcol-A is catalytically autoactivable and able to degrade synthetic peptides and type I and II fibrillar collagen. The enzyme is expressed predominantly during mouse embryogenesis, particularly in mouse trophoblast giant cells. Mcol-A may play roles as interstitial collagenase in murine tissues and is considered the ortholog of human MMP-1. The enzyme is being referred to also as
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