NDDCELCVNVACTGCL |
NDF |
hugin-PK |
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[NF-kappa-B-inducible DED-containing protein] NDED is a protein containing a DED domain. Its expression is induced by TNF-alpha and expression depends on the activation of the transcription factor NF-kappa-B. Provision of NDED in cells engineered to lack expression of NF-kappa-B inhibits apoptosis induced by TNF-alpha. NDED suppresses apoptosis mediated by TNF-alpha by inhibiting caspase-8 enzymatic activity but not the processing of caspase-8. NDED does not inhibit etoposide-mediated apoptosis, which is independent of caspase-8 activation.
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