PC12

A cell line established from a spontaneous rat pheochromocytoma derived from chromaffin cells of the suprarenal medulla. These undifferentiated cells resemble immature adrenal chromaffin cells. These chromaffin cells are related closely to sympathetic neurons and can differentiate into sympathetic neurons in the presence of NGF.

PC12 cells are used for studies of the biological effects of NGF and Neurotrophins. They have been used extensively to investigate the molecular biology of early response gene, which has led to the identification of many different TIS genes.

PC12 ... ... ... ...
 
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Entry last modified: July 2000