pCD25 |
PC cell-derived growth factor |
casein-alpha-s2(164-179) |
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[PC cell-derived growth factor] This factor of 88 kDa (68 kDa deglycosylated) and often referred to simply as GP88, is found in the conditioned medium of the PC cell line, a highly tumorigenic insulin-independent variant of the teratoma-derived adipogenic cell line 1246. PCDGF is the precursor for smaller proteins known as epithelins and/or granulins and is being referred to also as progranulin.
PCDGF is a growth-promoting activity for murine 3T3 fibroblasts and an autocrine growth modulator for the producer cells.
TRANSGENIC ANIMALS, KNOCK-OUT, AND ANTISENSE STUDIES
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