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PDGF-associated protein

abbr. PAP (an abbreviation with multiple meanings); abbr. also PAP1. The approved gene symbol is PDAP1 [PDGF-associated protein 1].

PAP was isolated from a rat neural retina cell line as a protein copurifying with PDGF A-chain (Fischer and Schubert, 1996). PAP mRNA is abundant in the brain of newborn rats and is found in several other tissues. PAP binds to PDGF with low affinity and enhances the mitogenic effect of PDGF-A but lowers the mitogenic activity of PDGF-B.

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