PTKs

[protein tyrosine kinase] Protein kinases are enzymes that attach phosphate residues to protein substrates.

Many cytokine receptors (see also: Cytokine receptor families) are transmembrane proteins with an extracellular domain that contains the ligand binding site and an intracellular domain encoding a tyrosine-specific protein kinase. The receptor tyrosine kinases (abbr. RTKs) constitute a family of more than 60 different proteins. With the exception of the insulin receptor these kinases are single polypeptide chains that pass through the membrane once. Based on details of their structural organization RTKs ... ... ... ...
 
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Entry last modified: June 2015