STIM1 |
Stimulated rat T-cell derived inhibitory factor for cellular DNA |
Met-Enk-RF |
||
[Stromal interaction molecule 2] The gene has been cloned by Williams et al (2001). The cDNA has been identified independently as KIAA1482. STIM2, together with STIM1, acts as a calcium sensor in the endoplasmic reticulum and plays a role in store-operated calcium entry following depletion of endoplasmic reticulum calcium stores (Liou et al, 2005). It has been shown to inhibit calcium entry mediated by STIM1, acting as a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels (Soboloff et al, 2006; Brandman et al, 2007) and mediates distinct store-dependent and store-independent modes of Ca2+ release-activated Ca2+ (CRAC) channel channel activation. (Parvezet al, 2008). Thiel et al (2013) have reported that STIM2 is activated preferentially by low-level physiological agonist
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |
| SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
|
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R