Spätzle

gene symbol: spz; often misspelled spatzle, spaetzle). Spätzle, encoded by gene CG6134, is a secreted Drosophila melanogaster cytokine that acts as a ligand for the Toll receptor and induces receptor dimerization (Weber et al, 2003; Hu et al, 2004). Spätzle exists in multiple isoforms (DeLotto et al, 2001). Parker et al (2000) have described 5 Drosophila homologs of Spätzle (Spätzle-2, Spätzle-3, Spätzle-4, Spätzle-5, Spätzle-6). All 5 proteins appear to encode proteins containing neurotrophin-like cystine knot domains and may represent activating ligands for distinct receptors related to the ... ... ... ...
 
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Entry last modified: September 2013