TNFSF19 |
TNFSF12-13 |
GWLRKIGKKIERVGQHTRDATIQVLGIAQQAANVAATARamide |
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[TNF ligand superfamily member 20] The human protein is a 285 amino acid long type 2 transmembrane protein and is one of the members of the TNF superfamily of proteins. TNFSF20 is expressed at the surface of antigen-presenting cells of the lineage of macrophages, monocytes, and dendritic cells. Surface expression of this protein is downregulated after exposure to bacterial lipopolysaccharides. The soluble form of recombinant TNFSF20 induces proliferation of resting peripheral blood monocytes and cell death by apoptosis of activated lymphocytes.
The protein isolated by Tribouley et al (1999) is identical with TNFSF13B
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