TNEIVEEQYTPQSLATLESVFQELGKLTGPNNQ |
TNFA |
sfRamos |
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[tumor necrosis factor] TNF was found originally in mouse serum after intravenous injection of bacterial endotoxins into mice primed with viable Mycobacterium bovis, strain Bacillus Calmette-Guerin (BCG). TNF was then shown to be present also in sera of rats, rabbits and guinea pigs. TNF-containing serum from mice is cytotoxic or cytostatic to a number of mouse and human transformed cell lines, but less or not toxic to normal cells in vitro. It causes necrosis of transplantable tumors in mice.
The two molecular species of TNF are known as
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