TRAIL receptor-3
abbr. TRAIL-R3. This human receptor (299 amino acids) for the cytotoxic ligand TRAIL belongs to the TNF receptor superfamily. The receptor is referred to also as TRID [TRAIL receptor without an intracellular domain]. The gene maps to human chromosome 8p22-21, clustered with the genes encoding two other TRAIL receptors.
Transcripts for this receptor are detectable only in peripheral blood lymphocytes and spleen.
Unlike the related TRAIL receptor-2 TRAIL receptor-3 does not contain a cytoplasmic death domain necessary for the induction of apoptosis. Because of its lack of a death domain
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