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TRANCE

[tumor necrosis factor-related activation induced cytokine] TRANCE is a member of the TNF family that was detected during a search for genes regulating cell death by apoptosis in murine cells.

The TRANCE gene encodes a type 2 membrane protein (N-terminus inside) of 316 amino acids with a predicted molecular mass of 35 kDa. TRANCE is identical with OPGL (Osteoprotegerin ligand), with OCIF, ODF, SOFA, and RANKL. Based on homology with other members of the TNF ligand protein superfamily these proteins are referred to also as TNF ligand superfamily member 11 [TNFSF11].

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