TRANCER |
Transactivator of Transcription |
folate hydrolase |
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[thioredoxin peroxidase-related activator of NF-kappa-B and c-Jun N-terminal kinase] This factor has been identified initially by sequence homology searches in the expressed sequence tag database. The predicted amino acid sequence of TRANK is highly homologous to that of the thiol-specific antioxidant proteins but contains a putative secretory signal polypeptide. The protein is secreted by cells (Haridas et al, 1998). TRANK has been given the gene symbol PRDX4 [peroxiredoxin-4] (abbr. also: PRX4). The human cDNA encoding TRANK has been cloned by Jin et al (1997), who referred to the encoded protein as AOE372 [antioxidant enzyme AOE372
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