TSTIF

[thymic stroma-derived T-cell inhibitory factor] This biochemically uncharacterized factor of approximately 20-25 kDa has been isolated from conditioned medium of one of the thymic stromal cell line, MRL104.8a.

The supernatant alone induces proliferation of T-helper cells because it contains IL7. The addition of the supernatant to cultures of T-helper cells stimulated with antigen plus antigen-presenting cells inhibits T-cell proliferation. TSTIF exerts its inhibitory effect on T-cell proliferation stimulated by antigens by acting on the antigen-presenting cells.

Several experiments demonstrate that the effects of TSTIF are not mediated by ... ... ... ...
 
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Entry last modified: March 1996